高伟 博士
讲师
临床医学系教师
电话：88285753 邮箱：gaoweizucc_1986@163.com 办公地址：浙大城市学院北校区理2-419
研究方向：肿瘤学，糖生物学
个人简介
高伟，讲师，浙大城市学院医学院基础教研室专职教师，主讲课程生物化学与分子生物学。长期致力于抗肿瘤新靶点发现和糖生物学相关机制探索，已发表SCI论文15篇。主持浙江省公益技术项目2项，浙江省卫生厅项目1项，带领学生参加浙江省生命科学竞赛并分别取得一等奖及三等奖，作为指导教师指导学生参加全国基础医学竞赛获得三等奖。
科研项目
1. 国家自然科学基金重点项目：干预肿瘤免疫检查点蛋白PD-L1的药物再发现研究（2020-2021）
2. 国家杰出青年科学基金（81625024）：肿瘤药理学（2017-2021）
3. 国家科技部创新人才推进计划（重点领域创新团队）：基于靶标的创新药物研究创新团队（2018）
发表论文
1.Zhang Q, Zhong C, Yan Q, Zeng LH, Gao W, Duan S. miR-874: An Important Regulator in Human Diseases. Front Cell Dev Biol. 2022 Apr 6;10:784968
2.Gao W, Liang J, Ye Y, Lu J, Lin T, Wang N, Dong J, Pan J. FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis. BMC Cancer. 2020 Sep 18;20(1):895.
3.Gao W , Liang JX, Ma C, Dong JY, Yan Q. The Protective Effect of N-Acetylcysteine on Ionizing Radiation Induced Ovarian Failure and Loss of Ovarian Reserve in Female Mouse. Biomed Res Int. 2017;2017:4176170
4.Gao W, Liang J, Liu S, Liu C, Liu X, Wang X and Yan Q. Oxidative damage of DNA induced by X-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction. International journal of clinical and experimental medicine. 2015，8(3):3401-10
5.Gao W, Liang J, Ge L, et al. Sterigmatocystin-induced oxidative DNA damage in human liver-derived cell line through lysosomal damage.Toxicol In Vitro. 2015, 29 (1): 1-7.
6.Gao W, Liang J, Yan Q. Exposure to radiation therapy is associated with female reproductive health among childhood cancer survivors: a meta-analysis study. J Assist Reprod Genet. 2015，32(8):1179-86
7.Liang JX, Liang Y, Gao W. Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis. Onco Targets Ther. 2016 May 24;9:3113-25.
6.Liang JX, Ning Z, Gao W, et al. Ubiquitinspecific protease 22 induced autophagy is correlated with poor prognosis of pancreatic cancer. Oncol Rep. 2014, 32(6): 2726-2734.
7.Liang JX, Gao W, Cai L. Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells. Onco Targets Ther. 2017 Aug 7;10:3971-3978.
8.Yao J, Ma C, Gao W, Liang J, Liu C, Yang H, Yan Q, Wen Q. Fentanyl induces autophagy via activation of the ROS/MAPK pathway and reduces the sensitivity of cisplatin in lung cancer cells.Oncol Rep. 2016 Dec;36(6):3363-3370.
9.Wang A, Lu C, Ning Z, Gao W, Xie Y, Zhang N, Liang J, Abbasi FS, Yan Q, Liu J. Tumor-associated macrophages promote Ezrin phosphorylation-mediated epithelial-mesenchymal transition in lung adenocarcinoma through FUT4/LeY up-regulation.
Oncotarget. 2017 Apr 25;8(17):28247-28259
10.Aziz F, Gao W, Yan Q. Fucosyltransferase-4 and Oligosaccharide Lewis Y Antigen as potentially Correlative Biomarkers of Helicobacter pylori CagA Associated Gastric Cancer.
Pathol Oncol Res. 2017 Jan;23(1):173-179.
教学与课程
目前担任本科生课程：《生物化学与分子生物学》、《生物化学（甲）》、《生物化学（乙）》、《医学科研》、《生命科学导论》等课程的本科教学。
社会兼职
1. 浙江省免疫学会 青年委员
