邵加安 博士
副教授 | 硕士生导师
药学系教师
电话：0571-88016565 邮箱：shaoja@zucc.edu.cn 办公地址：浙大城市学院北校区理1-419
研究方向：靶向药物设计及合成基于新化学方法的类药性化合物库的构建化药的工艺研究及改进
个人简介
邵加安，副教授，硕士生导师。从事基于新化学方法/策略的创新药物发现与药物创新工艺开发，主要围绕提高小分子药物的靶点选择性、拓展药物结构多样性、提升原料药合成工艺的绿色/原子经济性等关键科学问题开展研究。主持包括国家自然科学基金青年基金，中国博士后基金，浙江省自然基金等在内的课题5项。研究成果发表在Org. Lett., Bioorg. Med. Chem., Org. Biomol. Chem., Chem. Commun.等国际著名期刊，授权发明专利10余项。
科研项目
1. 浙江省自然科学基金探索项目：克服突变耐药的小分子EGFR抑制剂的设计，合成及生物活性筛选（2020-2022）
2. 国家自然科学基金青年基金：基于μ/δ受体双重活性减少毒副作用的吗啡类衍生物的设计、合成及活性评价（2017-2019）
3. 中国博士后科学基金第57批面上一等资助：具备μ/δ受体混合亲和性的新型吗啡类衍生物的研究（2015-2016）
4. 浙江省卫生厅科研计划项目：针对耐药非小细胞肺癌的小分子EGFR抑制剂的研究（2020-2022）
5. 杭州市农业与社会发展一般项目：PAN内切酶抑制剂的设计、合成及抗流感活性评价（2020-2022）.
研究与成果
1. 一种二芳甲酰基取代的吡唑类化合物及其制备方法；专利号：ZL202110158631.6；授权：中国
2. 二苯并呋喃丙烯酸酯类化合物及其制备方法；专利号：ZL201910554944.6 ；授权：中国
发表论文
近五年代表文章
1. Jiaan Shao*, Shuangrong Liu, Xingyu Liu, Youlu Pan, Wenteng Chen*. Design, Synthesis and SAR Study of 2-aminopyrimidines with Diverse Michael Addition Acceptors for Chemically Tuning the Potency Against EGFR(L858R/T790M)，Bioorganic & Medicinal Chemistry, 2020 28: 115680.
2. Fengkai Qiu, Yu Cao, Linghui Zeng, Chong Zhang, Liping Fu, Zhang Jiankang*, Huajian Zhu*, Jiaan Shao*. Substrate-Tuned Domino Annulation for Selective Synthesis of Polysubstituted Benzo[f]imidazo[2,1-a][2,7]naphthyridines and 3-Azaheterocyclic Substituted 2-Arylquinolines. The Journal of Organic Chemistry, 2021, 86( 13): 8997.
3. Tao Shi, Zhaoxiao Wu, Tingting Jia, Chong Zhang, Linghui Zeng, Rangxiao Zhuang, Jiankang Zhang, Shourong Liu*, Jiaan Shao*, Huajian Zhu*. Sequential [3+2] annulation reaction of prop-2-ynylsulfonium salts and hydrazonyl chlorides: synthesis of pyrazoles containing functional motifs. Chemical Communications, 2021, 57: 8460.
4. Tingting Jia, Gongruixue Zeng, Chong Zhang, Linghui Zeng, Wenya Zheng, Siyao Li, Keyi Wu, Jiaan Shao*, Jiankang Zhang*, Huajian Zhu*.The reaction of prop-2-ynylsulfonium salts and sulfonyl-protected beta-amino ketones to epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles. Chemical Communications, 2021, 57: 2657.
5. Zhimin Ying, Jie Cen, Feng Luo, You Wu, Shuangrong Liu, Wenteng Chen*, Jiaan Shao*, Yongping Yu*,Substrate-Tuned Domino Annulation for Selective Synthesis of Polysubstituted Benzo[f]imidazo[2,1-a][2,7]naphthyridines and 3-Azaheterocyclic Substituted 2-Arylquinolines. The Journal of Organic Chemistry, 2021, 86( 6): 4747-4755
6. Wenteng Chen, Feng Luo, You Wu, Jie Cen, Jiaan Shao*, Yongping Yu*. Efficient Access to Fluorescent Benzofuro[3,2-b]carbazoles via TFA-promoted Cascade Annulations of Sulfur Ylides, 2-hydroxy-β-nitrostyrenes and Indoles. Organic Chemistry Frontiers, 2020, 7: 882.
7. Jiaan Shao*, Wenteng Chen*, Zhimin Ying, Shuangrong Liu, Feng Luo, Lili Ou. Sulfur Ylide Initiated [4+1]/[4+2] Annulation Reactions: A One-pot Approach to Dibenzofuran Acrylate Derivatives，Organic Letters，2019, 21: 6370.
8. Jiaan Shao*, Wenteng Chen*, Menghao Zhao, Ke Shu, Huan Liu, Pai Tang. Substrate-controlled Synthesis of Spirocyclopropylpyrazolones and Bicyclic 4,5-dihydropyrazoles from 1,2-diaza-1,3-dienes with Sulfur Ylide，Organic Letters，2018，20 : 3992.
9. Wenteng Chen, Xingyu Liu, En Chen, Binhui Chen, Jiaan Shao*, Yongping Yu*. KI-mediated radical multi-functionalization of vinyl azides: a one-pot and efficient approach to beta-keto sulfones and alpha-halo-beta-keto sulfones，Organic Chemistry Frontiers, 2017, 4: 1162.
10. Jiaan Shao*, Richard A. Houghten, Colette T. Dooley, Margret Cazares, Jay P. McLaughlin, Shainnel O. Eans, Michelle L. Ganno, Michelle R. Hoot, Marc A. Giulianotti*, Yongping Yu*. A One-pot Multicomponent Approach to a New Series of Morphine Derivatives and Their Biological Evaluation, Organic & Biomolecular Chemistry, 2017, 15: 7796.
教学与课程
目前担任本科生课程：《药物化学》、《药物化学实验》、《药物合成反应》、《生物医药信息检索》等本科教学。
奖励荣誉
2017 台州市500精英
社会兼职
1. 浙江省药学会药物化学与抗生素青委会委员
2. 《中国现代应用药学》青年编委
实验室介绍
浙大城市学院北校区理1-712室
